DEAR DR. ROACH: I am a healthy male, age 66, nonsmoker, not overweight, who takes no medications. At my most recent annual physical, I mentioned to my physician that I was having symptoms of erectile dysfunction and wondered if that was typical for a man my age or if it could be due to low testosterone. He ordered normal blood tests as well as a testosterone test. All my numbers were in the normal range. My blood pressure runs a little high, but he said that as long as I kept it under 140/90 he wouldn’t put me on blood pressure medication.비아그라 구입
He prescribed sildenafil (Viagra), and I have taken it three times. The first dose was 60 mg. The subsequent doses have been 20 mg (one pill), which works as expected, except for one thing: About 30 minutes after taking it, my heart starts beating hard and fast. This happens off and on for several hours as the medication works through my system. This is mentioned as a “rare” side effect (1 in 1,000 people). Should I be concerned about this? It is a little scary to feel my heart beating so hard while relaxing in front of the TV, but it does eventually go away. Also, I am a little concerned about talking to my doctor about it because we don’t really know each other very well yet. Any thoughts? — M.비아그라 구매 ANSWER: My most important advice is that you should certainly discuss this with your doctor. It’s important, and you will get to know your new doctor more quickly by discussing something important like this. Sildenafil (Viagra) works by adjusting blood flow, and in the body, it acts mostly as a vasodilator. This commonly causes flushing, and the blood goes into blood vessels that are more open than usual. The heart will be affected. Blood pressure drops on average 6 points systolic and 4 points diastolic. In some people who take it, this can lead to the heart responding by beating a bit more forcefully and quickly. So, I would not be surprised by a person paying close attention to their body noticing that. An extra glass of water may help a bit with this side effect. In anyone who notices palpitations (the word just means an unpleasant sense of one’s own pulse, usually but not always fast or irregular), I recommend keeping a record of when it occurred and what you’re doing at the time. Include a careful measurement of the pulse rate and blood pressure, if you have a cuff at home. DEAR DR. ROACH: I am a 61-year-old woman who is gluten sensitive. Thus, I eat a number of gluten-free products to replace wheat and other grains in my diet. How safe is it to eat these products, which are mainly made from brown rice flour? I’m concerned that the amount of arsenic I am consuming may be dangerous. — A.K.S. ANSWER: Rice can contain higher levels of inorganic arsenic, a toxic metal, than most other cereal foods. This is particularly important for people with celiac disease, who often consume more rice than other people. Here are some things you should know to reduce arsenic exposure: — Rinsing and draining rice before cooking can reduce arsenic consumed by 50 percent. Consider cooking rice in more water than needed, draining excess water after cooking. — Brown rice tends to have more arsenic than white. — Rice from California, India and Pakistan tends to have less arsenic than rice from Arkansas, Louisiana and Texas.시알리스 구입 AdvertisementIt’s also important to use multiple other grains. Try grains like quinoa, buckwheat, amaranth and sorghum, and the flours made from them. * * * Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them in the column whenever possible. Readers may email questions to [email protected] or send mail to 628 Virginia Dr., Orlando, FL 32803. https://viagra-onlineshop.com/ 출처 : https://www.sunjournal.com/2019/05/03/heart-palpitations-are-a-rare-side-effect-of-viagra/
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For the first time ever, researchers investigate — in cellular detail — the damage that high levels of Viagra can do to the retina. Taking too much might threaten color vision.
How might a blue pill make you see red?There are few drugs as well-known as sildenafil citrate, commonly sold under the brand name Viagra.비아그라 구입 Scientists initially trialed the drug as a potential treatment for angina and other cardiovascular problems. Though it had little effect on angina, they noted that it induced significant penile erections. So, the most successful erectile dysfunction drug was born. Viagra is pharmaceutical giant — Pfizer's best selling product, generating the company more than $1 billion in revenue each year. The drug has, no doubt, improved the lives of many of its users; but, according to a new study, it may have a negative impact on vision if used incorrectly. Red-tinted visionResearchers from the Icahn School of Medicine at Mount Sinai in New York City, NY, have recently published a case study in the journal Retinal Cases and Brief Reports. They conclude that using higher doses of Viagra could eventually lead to significant long-term vision damage. Lead investigator Dr. Richard Rosen claims, "People live by the philosophy that if a little bit is good, a lot is better. This study shows how dangerous a large dose of a commonly used medication can be." In particular, the researchers showed that the drug might impact color vision most heavily. "People who depend on colored vision for their livelihood need to realize there could be a long-lasting impact of overindulging on this drug."시알리스 구입 Dr. Richard Rosen The researchers made their conclusions based on a study on a 31-year-old male "who arrived at an urgent care clinic complaining of red-tinted vision in both eyes" that had not improved for 2 days. His vision changes had started soon after taking sildenafil citrate, which he had purchased from the Internet. The patient had taken well over the recommended 50-milligram dose. Although the side effects of sildenafil citrate can include vision disturbances, they do not persist for longer than 1 day. However, despite various treatments, his vision did not return to normal after 1 year. 광고 inRead invented by TeadsCutting-edge imaging techniquesIn order to investigate the man and uncover the details of his vision changes, the researchers used cutting-edge techniques including adaptive optics (AO) and optical coherence tomography (OCT). AO allows clinicians to study the microscopic structures of the eye in living tissue in real-time. It makes it possible to view the individual rods and cones of the retina. AO has already led to significant improvements in our understanding of how the retina functions. Persistent stress may lead to vision loss, study shows A recent analysis of existing research concludes that "stress is both a consequence and cause of vision loss." READ NOWOCT, first used to image a retina in a live animal in the 1990s, allows physicians to view the retina in cross-section, giving a clear picture of its layered structure. Today, it is used to help diagnose conditions such as glaucoma and diabetic retinopathy. Using these techniques, the team looked in detail at the cellular makeup of the man's retina and investigated it for Viagra-induced damage. They saw that the cones of the eye — which are responsible for color vision — were damaged. The changes that they measured were similar to those seen in animal models of retinitis pigmentosa or cone-rod dystrophy, both of which are hereditary diseases of the retina. The changes came as a surprise to Dr. Rosen, who says, "To actually see these types of structural changes was unexpected, but it explained the symptoms that the patient suffered from." "While we know colored vision disturbance is a well-described side effect of this medication," he notes, "we have never been able to visualize the structural effect of the drug on the retina until now." The scientists hopes that their findings will be useful for clinicians when they are talking to their patients about the potential dangers associated with Viagra. As Dr. Rosen continues, "Our findings should help doctors become aware of potential cellular changes in patients who might use the drug excessively, so they can better educate patients about the risks of using too much." https://viagra-onlineshop.com/ As the paper is an in-depth study of just one person, further studies — using more participants — will be important. However, the study does bring a new level of detail and provides a unique picture of the damage that high doses of Viagra can cause. Although these findings are concerning, it is worth remembering that millions of men use Viagra worldwide. When taken as advised by a doctor, serious side effects are rare. 출처 : https://www.medicalnewstoday.com/articles/323234.php Organic or so-called "natural" products are all the craze. People wrongly believe, often because of purposefully misleading advertising, that these products are safer and healthier than other products.
One of the biggest offenders in this regard are dietary supplements, which are poorly regulated. These products can make all sorts of unproven claims as long as they include a disclaimer saying that the FDA hasn't evaluated them. As you can imagine, this allows for unscrupulous behavior, such as labeling vitamin C tablets with questionable assertions like, "Helps support the immune system."*비아그라 구매 Other products are far worse. One company selling a product known as Leopard Miracle Honey has apparently spiked it with Viagra. All-Natural 'Miracle Honey' Spiked with Viagra Miracle Honey really is miraculous. According to its website, the honey will "heal sexual impotence and sterility." Wow, that's good honey! How does honey, which isn't all that different from high-fructose corn syrup, make a man pop a boner? Well, they claim it's due to a special concoction of "rainforest herbs: Tongkat Ali root, Ginseng root, Carob and Cinnamon powder." (See image of the product's ingredient list, provided by the FDA.)비아그라 구입 Why should an impotent man use their product instead of seeing his doctor? Well, because "running to synthetic chemical drugs carries the weight of dangerous side effects." So, no synthetic chemicals in Miracle Honey. No sir! Okay, there might be one: Viagra. A notification on the FDA's website says that a voluntary recall of Miracle Honey has been issued due to the presence of undeclared sildenafil. That's the generic name for Viagra. In other words, the actual secret ingredient in Miracle Honey is a synthetic drug produced by Big Pharma. No wonder its website says that its all-natural, herb-infused honey should "not to be used by patients with kidney failure, heart disease, chronic hypertension, ischemia, and children under 18 years old." This makes sense since Viagra comes with a similar warning. They didn't want to accidentally kill somebody. Fraud in the 'Natural' Products and Supplements Industry Just how common is this sort of potentially lethal fraud? It's hard to say, but my colleague Dr. Josh Bloom just reported on a supplement called "Blue Fusion" that included not one, not two, but six undeclared drugs, four of which were for treating erectile dysfunction. Gents, if your pocket rocket is no longer ready for liftoff, put down the herbal supplements and go see your doctor.시알리스 구매 *Note: This is questionable because (1) nobody needs to take a vitamin C supplement unless he's a British sailor from the 18th Century; and (2) there is very little evidence for the widespread belief that vitamin C helps prevent colds. https://viagra-onlineshop.com/ 출처 : https://www.acsh.org/news/2019/03/29/all-natural-miracle-honey-spiked-viagra-13914 A recent series of studies, funded by Sprout Pharmaceuticals, show that Addyi, also known as the “female viagra,” is potentially safe with moderate alcohol use. However, some experts aren’t convinced — and neither is the FDA.비아그라 구입
Share on Pinterest According to current FDA rules, women using Addyi not only have to be counseled to abstain from all booze, but sign an agreement form promising to do so. Getty ImagesIn 2015, the Food and Drug Administration (FDA) approved Addyi (flibanserin), a prescription medicine heralded as a long overdue “female Viagra.” It also slapped a black box warning on the package to call attention to side effects of the drug considered serious or life-threatening. Chief among them: women who took the drug while drinking alcohol ran the risk of losing consciousness. Recently, Addyi’s manufacturer, Sprout Pharmaceuticals, announced results of some new research in hopes of getting that concerning warning removed. “The additional insights provided by these three new studies are invaluable for a more comprehensive understanding of Addyi for safe use,” said Cindy Eckert, founder and CEO of Sprout Pharmaceuticals, in a press release. “This additional data contextualizes and further clarifies the relationship between Addyi and alcohol.”시알리스 구입 Yet some experts aren’t convinced it proves the drug is safe to take with alcohol — and neither is the Food and Drug AdministrationTrusted Source (FDA). Based on the results of the new studies, Sprout must change their labeling to clarify the risks of drinking alcohol close in time to taking Addyi. What Addyi isAddyi is the first and only FDA-approved treatment of Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women. The condition is just what it sounds like: basement-level libido to the point of personal distress. The American Sexual Health Association reports that 1 in 10 women have HSDD. By tweaking brain chemistry, Addyi purports to help HSDD. It lowers serotonin, which can impede sexual desire, while helping to fire up other neurotransmitters, like norepinephrine, which are believed to boost interest in sex. The FDA rejected Addyi twice, citing both small effects and major safety concerns like low blood pressure that can lead to a sudden and prolonged loss of consciousness. These risks increase when Addyi is taken with certain other drugs or alcohol. Finally allowing that HSDD is an “unmet medical need,” the FDA approved Addyi on its third review, with a few caveats. Aside from the black box warning, only certified doctors and pharmacies who’ve completed special training can prescribe or dispense the drug. Patients not only have to be counseled to abstain from all booze, but sign an agreement form promising to do so. Their doctor has to sign, too. At that time, the FDA also noted that Addyi’s interaction with alcohol hadn’t been adequately studied. One safety study, for instance, enrolled 23 men and only two women, even though this is a drug for women. Three post-approval trials from Sprout were required to dig a little deeper. What the studies showOf the three new studies funded by Sprout, the smallest one was designed to simulate a “real world scenario.” For three days, 24 healthy premenopausal women took either Addyi or a placebo. Then on the fourth and sixth day, they had either two alcoholic or nonalcoholic drinks with dinner, plus either Addyi or a placebo two and a half hours later at bedtime. No one fainted. A second study with 96 women was arranged as a “worst-case scenario,” in which Addyi was taken along with two or three drinks and consumed within 10 minutes in the morning following an overnight fast and light snack. No episodes of fainting or dangerously low blood pressure requiring medical care were observed, although participants did feel drowsier. The last study tested the impact of drinking alcohol when taking Addyi. Sixty-four healthy women were given either a single daily dose of Addyi or a placebo for three days. On days 4, 6, 8, and 10, they then had two alcoholic drinks 2, 4, or 6 hours prior to taking Addyi or a sugar pill. Like the other studies, there were no reported episodes of fainting or low blood pressure. 광고 What the studies mean“The largest study is really a ‘worst-case scenario’ where the drug was delivered during the day to almost 100 women. That [study] didn’t show any issue, how many more would you need?” said Dr. James A. Simon, CCD, NCMP, IF, FACOG, clinical professor of OB/GYN at George Washington University School of Medicine, medical director at IntimMedicine Specialists in Washington, D.C., and the primary researcher on the study. https://viagra-onlineshop.com/ “If you look at the actual clinical trials, the six-month trials,” Simon continued, “the incidence of hypotension and syncope are about equal, slightly more, in the Addyi group than the placebo, but not statistically different. About 60 percent of women were social drinkers in the trials, and even in the Addyi group, the incidence of hypotension and syncope were under 1 percent.” However, experts who weren’t associated with the research were less enthusiastic about the results. “These studies don’t seem very persuasive to me,” said Diana Zuckerman, PhD, president of the National Center for Health Research. “They are a good start, but they’re not very big and certainly aren’t very long. The cumulative effect of taking this drug could be quite different.” For instance, what happens if a woman taking Addyi drinks two days a week for a month? Or every day for a month? All the studies tell us, Zuckerman said, is what may happen if a woman taking Addyi drinks exactly like the other women in the studies. And even that’s not a guarantee since “not everyone will metabolize the drug or the alcohol the same way,” Zuckerman said. Dr. G. Thomas Ruiz, OB/GYN lead at MemorialCare Orange Coast Medical Center in Fountain Valley, California, agreed. “The way something is studied is not what goes on in real life,” Ruiz said, adding Sprout will need much larger studies to convince the FDA to alter Addyi’s packaging. “It’s very unusual for the FDA to remove black box warnings. Pharmaceutical companies have to go through extraordinary means to get that removed.” Plus, noted Ruiz, Addyi still interacts with many other medicines that are commonly prescribed to women and which can cause the same adverse side effects as alcohol. These include oral medicines used to treat yeast infections, antibiotics, high blood pressure medications, and antihistamines like over-the-counter Benadryl. Taking combined oral contraceptives at the same time as Addyi may make you more likely to experience an adverse reaction. After reviewing the study results, the FDA decided that changes should be made to Addyi’s labeling, but that black box warning isn’t going anywhere. Instead, it and other sections of Addyi’s labeling will be updated to reflect that women don’t need to abstain from alcohol completely, but should stop imbibing at least two hours before taking Addyi at bedtime or skip their dose of Addyi that evening. And if Addyi is taken at bedtime, no booze should be consumed at least until the morning after. If you try AddyiIf your libido could use a boost and you’re interested in trying Addyi, keep in mind: It’s not for everyone. “The guidelines to use it are very rigid and women need to be aware of that,” Ruiz said. For instance, Addyi can’t be prescribed to menopausal women or anyone with a history of depression. Watch your booze intake. Take these new FDA guidelines seriously. And keep in mind: Despite what these studies show, the FDA warnings pertaining to alcohol and Addyi remain unchanged. So, you’ll need to play it safe and abstain from drinking altogether. “Alcohol can cloud your judgment. This drug could cloud it even more,” warns Zuckerman. 비아그라 구매 Be vigilant about your meds. Don’t assume your doctor or pharmacist will remember that you’re taking Addyi. Remind them before you’re prescribed, or begin taking, any additional meds. That goes for over-the-counter drugs and herbal supplements too. It’s not a magic pill. According to the prescribing information on the company’s website, researchers found that the drug only added one additional “satisfying sexual encounter” per month. “Low libido is something that’s hard to deal with. Usually, in my experience, there’s an underlying issue causing it,” said Ruiz. That could be a problem in your relationship, inhibitions about sex, or poor body image, all of which may be helped by counseling. 출처 : https://www.healthline.com/health-news/new-study-show-female-viagra-drug-claim-medication-is-safe-to-take-with-alcohol-company-seeks-changes-to-fda-labeling#If-you-try-Addyi |
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